Unable to connect or upgrade pixhawk

Hi, I have a Pixhawk board from 3DR, the board working correctly in flight and with telemetry but from usb connection I'm not able to communicate with the board.

I'm using mission planner and I already tried to change usb cable, pc, OS and sd Card.

When I try to connect, mission planner return an error (see image attachmed).

When I try to upload a firmware, mission planner detect an apx4v2 and then ask to unplug the board, press ok and plug in back, but after doing so, it reports "No Response from board".

Does anyone have any idea what it is?

Thanks

mission_planner.png

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