PixHawk Mini problems on a quad

I installed a PixHawk Mini on a quad and am having some interesting problems when I throttle up.  The motors all oscillate and the quad vibrates terribly.  I've flown this quad with these motors and speed controls before with know issues.  Anyone know where I should start troubleshooting?  I've flown multiple quads and fixed wing planes with Ardupilots and PixHawks but I've never run into anything like this: 

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